Scientists

Speakers

Richárd Fiáth

Speaker at

Advanced neurotechnologies for brain activity monitoring and modulation 

12:00 - 13:30 16th October, 2022 

Richárd Fiáth

Research Centre for Natural Sciences, Budapest, Hungary

Richárd Fiáth

Speaker at

Advanced neurotechnologies for brain activity monitoring and modulation 

12:00 - 13:30 16th October, 2022 

Symposium Description

There is a growing interest and need in the development and use of innovative neural recording and modulation technologies to capture and manipulate the activity of the brain. Approaches to modulate neural activity are especially important since these might have a significant therapeutic potential for the treatment of various neurological disorders. The presenters of this symposium will highlight recent technological innovations developed for invasive neuroscience experiments performed in animal models. The Invited Speaker (Zoltán Fekete, group leader) will give a brief summary of the field of infrared neuromodulation and demonstrate the development and in vivo validation of a multifunctional device providing infrared stimulation. The next speaker will present a silicon-based optrode composed of an
integrated microfluidic channel for the injection of virally delivered optogenetic constructs, an optical glass fiber for photostimulation and small recording sites to obtain neural activity (Kirti Sharma, PhD student). Assessment of electrophysiological performance and biocompatibility of such optrodes chronically implanted in the neocortex of rats will be detailed. The last two presenters of the symposium will demonstrate high-density electrophysiological devices and their application in neuroscience research: transparent and flexible microelectrocorticography (μECoG) arrays developed for combined electrophysiological and optical (intrinsic optical imaging and calcium imaging) recordings (Zsófia Lantos, Phd student), and silicon-based planar neural probes with a high number of tightly packed recording sites applied for high spatial resolution electrical imaging of single neuron activity (Csaba Horváth, Phd student). 

Talk: "Evolution of silicon-based probes developed for large-scale neuronal recordings"

Penetrating neural probes were developed with the intention to record or to modulate the electrical activity of neurons located close to the implanted probe shank. First planar silicon-based devices designed for in vivo experiments contained only a few recording sites on a single shank monitoring the activity of a limited number of neurons, while the current technology used to fabricate state-of-the-art silicon probes allows the placement of over a thousand recording sites on a single or on multiple silicon shanks. This impressive engineering achievement was accomplished by the application of complementary metal-oxide-semiconductor (CMOS) technology which also resulted in a remarkable increase in the spatial resolution of these in vivo recordings. The resulting high-density, high-channel-count measurements usually contain the extracellular electrical activity of hundreds of neurons obtained simultaneously from multiple brain areas. This lecture gives a brief overview of the history of silicon-based neural probes, introduces their main features and highlights the main applications of these tools. 

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