Gaia Novarino

Gaia Novarino

IST, Austria

Gaia Novarino


Gaia Novarino is a professor of Institute of Science and Technology, Klosterneuburg, Austria. Prof. Novarino obtained her Ph.D. in developmental biology from the La Sapienza University (Rome, Italy) in 2006. During the Ph.D studies she moved to Germany to join the Max Delbruck Center for Molecular Medicine where she focused on the study of chloride transporters associated with human genetic disorders. In 2010 she started a postdoc at the School of Medicine of University of California, San Diego researching the genetics of epilepsy, autism and intellectual disability. In 2014, prof. Novarino joined the Institute of Science and Technology Austria (ISTA), first as Assistant Professor and then as Full Professor.

Studying the genes underlying inherited forms of neurodevelopmental disorders remains the mainfocus of her research. The Novarino Group at ISTA currently investigates the role of the SETD5 gene in intellectual disability, modeling epileptic encephalopathies and autism spectrum disorders in human brain organoids as well as the role of branched aminoacid-dependent pathways in neurodevelopmental disorders. Their recent publication topics include the role of large neutral aminoacid levels in tuning perinatal neuronal excitability and survival, and the cytoskeleton protein homeostasis and cell migration during acritical window of brain development.
Prof. Gaia Novarino holds a plethora of prestigious awards and grants, including the ERC grant, the Boehringer Ingelheim FENS Research Award. She is a FENS-Kavli Network of Excellence alumni, a Simons foundation Investigator, and since 2021 the Vice Presidents for Science Education at IST Austria.

Selected Publications

Deliu, E., Arecco, N., Morandell, J., Dotter, C. P., Contreras, X., Girardot, C., Käsper, E. L., Kozlova, A., Kishi, K., Chiaradia, I., Noh, K. M., & Novarino, G. (2018). Haploinsufficiency of the intellectual disability gene SETD5 disturbs developmental gene expression and cognition. Nature neuroscience21(12), 1717–1727.

Novarino, G., Fenstermaker, A. G., Zaki, M. S., Hofree, M., Silhavy, J. L., Heiberg, A. D., Abdellateef, M., Rosti, B., Scott, E., Mansour, L., Masri, A., Kayserili, H., Al-Aama, J. Y., Abdel-Salam, G. M. H., Karminejad, A., Kara, M., Kara, B., Bozorgmehri, B., Ben-Omran, T., Mojahedi, F., … Gleeson, J. G. (2014). Exome sequencing links corticospinal motor neuron disease to common neurodegenerative disorders. Science (New York, N.Y.)343(6170), 506–511.

Novarino, G., El-Fishawy, P., Kayserili, H., Meguid, N. A., Scott, E. M., Schroth, J., Silhavy, J. L., Kara, M., Khalil, R. O., Ben-Omran, T., Ercan-Sencicek, A. G., Hashish, A. F., Sanders, S. J., Gupta, A. R., Hashem, H. S., Matern, D., Gabriel, S., Sweetman, L., Rahimi, Y., Harris, R. A., … Gleeson, J. G. (2012). Mutations in BCKD-kinase lead to a potentially treatable form of autism with epilepsy. Science (New York, N.Y.)338(6105), 394–397.

Parenti, I., Rabaneda, L. G., Schoen, H., & Novarino, G. (2020). Neurodevelopmental Disorders: From Genetics to Functional Pathways. Trends in neurosciences43(8), 608–621.

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