Sebastian Haesler

Sebastian Haesler

NERF, Belgium

Sebastian Haesler


Sebastian Haesler is a professor of Neuroscience at the Katholieke Universiteit Leuven and Director of Neuroelectronics Research Flanders (NERF). He received his Ph.D. degree from the Max-Planck-Institute for Molecular Genetics, Berlin, Germany, in 2006. Next, he did his post-doctoral work with the Center for Brain Science, Harvard University, Cambridge, MA, USA, with support from the Human Frontiers Science Program. Since 2013, prof. Haesler occupies his current position at KU Leuven, and directs NERF since 2015. 

In his work he studies the brain by mechanistically dissecting fundamental information processing problems using mice as model animals. In particular, the Haesler Lab focuses on analyzing the ability to discriminate novel from familiar sensory stimuli. Additionally, the team develops novel brain interfaces to undertake current problems and limitations in manipulating the brain and effectively measuring its activity. These technologies are aimed to be designed in a way to find clinical and research applications.  

Publication topics include the study of neural circuts underlying exploration and curiosity, and the design of the synaptrode-a device where electrodes make synapse-like connections with selected subpopulations of neurons enabled by the molecular code of cell adhesion molecules. Overall, techniques most commonly used by the team range from magnetic resonance imaging (MRI), through neurophysiological recordings, to brain-computer intefaces, providing an interdisciplinary approach to current neuroscience issues. 

Selected Publications

 (2022). Actively Multiplexed μECoG Brain Implant System With Incremental- ΔΣ ADCs Employing Bulk-DACs. IEEE Journal of Solid-State Circuits..

 (2021). Implantation of Neuropixels probes for chronic recording of neuronal activity in freely behaving mice and ratsNature Protocols.

 (2020). Cue-Evoked Dopamine Promotes Conditioned Responding during LearningNeuron. 

 (2020). Failure Modes of Implanted Neural InterfacesNeural Interface Engineering: Linking the Physical World and the Nervous System.

More information

Heasler lab

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